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Mir-675 microRNA precursor family : ウィキペディア英語版 | Mir-675 microRNA precursor family
In molecular biology mir-675 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. ==Inhibition of cell proliferation== miR-675 overexpression brings about reduced proliferation in a range of embryonic and extraembryonic stem cell lines. It has been found to be embedded in the first exon of the large intergenic non-coding RNA H19, which is responsible for limiting placental growth prior to birth. There is upregulation of the targets of miR-675 in placentas lacking H19; these include the insulin-like growth factor 1 receptor (IGF1R). Thus placentas lacking miR-675 continue to grow. It is possible that controlled miR-675 release from H19 may enable a rapid inhibition of cell proliferation in response to cellular stress or oncogenic signals.
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